Plan Huila 2050 is the first comprehensive climate change plan for a department in Colombia. This USAID-funded project was developed in one of the most strategic regions of the country because of its water potential (the Magdalena River is born), energy generation and the dynamism of its agricultural sector (coffee, rice and beans). This project made it possible to create a long-term territorial vision and to prioritize actions with public and private authorities in strategic sectors such as water, biodiversity and ecosystem services, agriculture, energy and models of resilient municipalities. In addition, this project made it possible to measure greenhouse gas emissions, project the future climate vulnerability of its 39 municipalities and generate a pioneering diagnosis of financial sources for climate change. Today, the CAM and the Governor’s Office of Huila are promoting the implementation of the Huila 2050 Plan, and municipalities such as Pitalito have become models for other rural municipalities in the country by becoming leaders that promote an agenda and concrete actions for adaptation to climate change.